Simplified “No-D” NMR Methods for Routine Analysis and Organometallic Reagent Concentration Determination

The use of tetrachloroethylene spiked with tetramethylsilane as a solvent for routine NMR analysis has been evaluated. Excellent quality spectra are reliably obtained, comparable to samples run in chloroform-d. Validation of this method is presented, together with the spectral data of commonly encountered trace impurities. In addition, NMR analysis for the concentration determination of organometallic reagents has been simplified using double-walled NMR tubes using a calibrated external reference solution within a hermetically sealed chamber.